Drug General Information
Drug ID	D0U7HD
Former ID	DIB005933
Drug Name	SQ-33961
Indication	Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Terminated	[544974]
Company	Squibb Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(nc(co1)C(=O)NCCCCC1CCCCC1)[C@H]1[C@H]([C@H]2O[C@@H]1<br />CC2)Cc1c(CCC(=O)O)cccc1
CAS Number	CAS 139067-88-2
Target and Pathway
Target(s)	Thromboxane A2 receptor	Target Info	Modulator	[551648]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Platelet activation
Reactome	Prostanoid ligand receptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
	Thromboxane signalling through TP receptor
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544974	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001755)
Ref 551648	Conformationally-restricted analogs of TXA2 antagonist SQ 33,961: Receptor binding conformation of the carboxyl sidechain. Bioorganic & Medicinal Chemistry Letters Volume 1, Issue 9, 1991, Pages 465-470.

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