Drug Information

Drug General Information
Drug ID
D07FHZ
Former ID
DNC001219
Drug Name
Ro 20-1724
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Terminated [540721], [545620]
Structure
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2D MOL

3D MOL
Formula
C15H22N2O3
InChI
InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
InChIKey
PDMUULPVBYQBBK-UHFFFAOYSA-N
CAS Number
CAS 29925-17-5
PubChem Compound ID
5087
PubChem Substance ID
5146344, 7980528, 8153130, 11121423, 11121903, 11362492, 11364754, 11365054, 11367316, 11367616, 11369878, 11370255, 11370256, 11373070, 11373217, 11375778, 11378043, 11491641, 11495654, 14824380, 17404767, 24278195, 26613194, 26747110, 26751709, 26759463, 29224155, 46500386, 47216899, 47662431, 47810881, 48185112, 48259380, 48259381, 48478658, 50067170, 50070586, 50071197, 50104396, 50104397, 50104398, 50104399, 53777310, 53789843, 53800559, 57322600, 80110624, 85084418, 85230941, 85787734
Target and Pathway
Target(s) CAMP-phosphodiesterase Target Info Inhibitor [537933]
References
Ref 540721(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5258).
Ref 545620Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003923)
Ref 537933Increased interleukin-4 production by atopic mononuclear leukocytes correlates with increased cyclic adenosine monophosphate-phosphodiesterase activity and is reversible by phosphodiesterase inhibition. J Invest Dermatol. 1993 May;100(5):681-4.

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