Drug Information

Drug General Information
Drug ID
D0E3BH
Former ID
DAP000469
Drug Name
Ridogrel
Synonyms
Ibidel; R-68070; Ridogrel (USAN/INN); 5-[(E)-[pyridin-3-yl-[3-(trifluoromethyl)phenyl]methylidene]amino]oxypentanoic acid
Drug Type
Small molecular drug
Indication Acute myocardial infarction [ICD9: 410; ICD10:I21-I22] Approved [536491]
Therapeutic Class
Gastrointestinal Agents
Structure
Download
2D MOL

3D MOL
Formula
C18H17F3N2O3
Canonical SMILES
C1=CC(=CC(=C1)C(F)(F)F)C(=NOCCCCC(=O)O)C2=CN=CC=C2
InChI
1S/C18H17F3N2O3/c19-18(20,21)15-7-3-5-13(11-15)17(14-6-4-9-22-12-14)23-26-10-2-1-8-16(24)25/h3-7,9,11-12H,1-2,8,10H2,(H,24,25)/b23-17+
InChIKey
GLLPUTYLZIKEGF-HAVVHWLPSA-N
CAS Number
CAS 110140-89-1
PubChem Compound ID
5362391
PubChem Substance ID
7980514, 11654074, 12014065, 14926245, 39384490, 46506774, 47207388, 50256442, 57362095, 85209998, 103189091, 103917719, 114150025, 124976970, 134964201, 137021276, 152090766, 160964540, 179149576, 198969038, 226402381
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Binder [537194]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 536491Inhibition of cytochromes p450: existing and new promising therapeutic targets. Drug Metab Rev. 2007;39(2-3):481-99.
Ref 537194Chronic ouabain treatment exacerbates blood pressure elevation in spontaneously hypertensive rats: the role of vascular mechanisms. J Hypertens. 2009 Jun;27(6):1233-42.

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