Drug General Information
Drug ID	D01ZJM
Former ID	DIB015989
Drug Name	R-1479
Synonyms	R1626; 4-Azidocytidine
Drug Type	Small molecular drug
Indication	HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10:B17.1, B18.2]		Discontinued in Phase 1	[547741]
Company	Roche Holding AG
Structure		Download 2D MOL 3D MOL
Formula	C9H12N6O5
Canonical SMILES	C([C@@]1([C@H]([C@H]([C@@H](O1)n1c(=O)nc(cc1)N)O)O)N=[N<br />+]=[N-])O
CAS Number	CAS 478182-28-4
PubChem Compound ID	457388
Target and Pathway
Target(s)	RNA polymerase	Target Info	Inhibitor	[527900]
KEGG Pathway	Purine metabolism
	Pyrimidine metabolism
	Metabolic pathways
	RNA polymerase
References
Ref 547741	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018944)
Ref 527900	The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. J Biol Chem. 2006 Feb 17;281(7):3793-9. Epub 2005 Nov 29.

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