Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09AYQ
|
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| Former ID |
DNC003511
|
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| Drug Name |
PIRITREXIM
|
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| Drug Type |
Small molecular drug
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C17H19N5O2
|
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| InChI |
InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22)
|
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| InChIKey |
VJXSSYDSOJBUAV-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
585461, 596153, 5321568, 7889090, 8183612, 12012913, 14801638, 26704486, 34718371, 46506046, 46518330, 50035075, 50293384, 85866344, 93579418, 103165437, 103855306, 104304731, 126420216, 129485784, 134340716, 135029179, 137008239, 143157948, 160966790, 163724435, 172896495, 178103986, 179151032, 198977797, 208012006, 219402188, 223518945, 225249588, 226399387, 241132020
|
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| Target and Pathway | |||||
| Target(s) | DHFR | Target Info | Modulator | ||
| PANTHER Pathway | Tetrahydrofolate biosynthesis | ||||
| Formyltetrahydroformate biosynthesis | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| PathWhiz Pathway | Folate Metabolism | ||||
| Pterine Biosynthesis | |||||
| References | |||||
| Ref 521445 | ClinicalTrials.gov (NCT00002914) Piritrexim in Treating Patients With Advanced Cancer of the Urinary Tract. U.S. National Institutes of Health. | ||||
| Ref 542438 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7414). | ||||
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