Drug Information

Drug General Information
Drug ID
D02VUX
Former ID
DCL000595
Drug Name
PF-217830
Synonyms
PF-00217830; 7-[4-(4-naphthalen-1-ylpiperazin-1-yl)butoxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
Drug Type
Small molecular drug
Indication Bipolar disorder; Schizophrenia [ICD9: 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300, 295; ICD10:F31, F40-F42, F20] Discontinued in Phase 2 [548438]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C26H30N4O2
Canonical SMILES
C1CC(=O)NC2=C1C=CC(=N2)OCCCCN3CCN(CC3)C4=CC=CC5=CC=CC=C<br />54
InChI
1S/C26H30N4O2/c31-24-12-10-21-11-13-25(28-26(21)27-24)32-19-4-3-14-29-15-17-30(18-16-29)23-9-5-7-20-6-1-2-8-22(20)23/h1-2,5-9,11,13H,3-4,10,12,14-19H2,(H,27,28,31)
InChIKey
QGNOXTFZOLDODX-UHFFFAOYSA-N
PubChem Compound ID
11697676
PubChem Substance ID
16802186, 23790965, 42864589, 79604947, 99431621, 131282709, 131346213, 138233113, 138866168, 227390897, 248688290
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Modulator
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 548438Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025560)

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