Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0J5QW
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| Former ID |
DIB006567
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| Drug Name |
ON-579
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD10:J45] | Terminated | [1] | ||
| Company |
Taisho Pharmaceutical Co Ltd
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| Structure |
|
Download2D MOL |
|||
| Formula |
C16H14ClF2NO5S2
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| Canonical SMILES |
S(=O)(=O)(c1ccc(cc1)Cl)NCCSc1cc(c(c(c1)F)OCC(=O)O)F
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| CAS Number |
CAS 141286-14-8
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Thromboxane A2 receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Platelet activation | |||||
| Reactome | Prostanoid ligand receptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (12/13) signalling events | |||||
| Thromboxane signalling through TP receptor | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Signal amplification | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003601) | ||||
| REF 2 | The effect of a TXA2 receptor antagonist ON-579 on experimental allergic reactions. Prostaglandins Leukot Essent Fatty Acids. 1995 Aug;53(2):123-33. | ||||
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