Drug General Information
Drug ID	D05FFR
Former ID	DNC000944
Drug Name	MGBG
Drug Type	Small molecular drug
Indication	Head and neck cancer [ICD9: 140-149, 140-229; ICD10:C07-C14, C32-C33]		Terminated	[525957], [535793]
Structure		Download 2D MOL 3D MOL
Formula	C5H12N8
Canonical SMILES	CC(=NN=C(N)N)C=NN=C(N)N
InChI	1S/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13)/b10-2+,11-3+
InChIKey	MXWHMTNPTTVWDM-NXOFHUPFSA-N
CAS Number	CAS 13922-04-8
PubChem Compound ID	5351154
PubChem Substance ID	611216, 7888899, 12012645, 15195228, 39377781, 49974828, 51091596, 57361327, 77105216, 85301076, 103504484, 103977023, 113903809, 118049580, 124633349, 126591589, 126688706, 131315453, 132511295, 134340069, 134340223, 134340226, 134973137, 136352263, 137241210, 140630209, 164825287, 179225924, 179226390, 179685434, 223442568, 223670665, 226399648, 227917561, 237032998, 241088157, 249691017, 252559424, 252669978
SuperDrug ATC ID	L01XX16
SuperDrug CAS ID	cas=000459869
Target and Pathway
Target(s)	S-adenosylmethioninedecarboxylase proenzyme	Target Info	Inhibitor	[535032], [535955]
BioCyc Pathway	Methionine salvage cycle III
	Spermine biosynthesis
	Spermidine biosynthesis
KEGG Pathway	Cysteine and methionine metabolism
	Arginine and proline metabolism
	Metabolic pathways
NetPath Pathway	EGFR1 Signaling Pathway
PathWhiz Pathway	Spermidine and Spermine Biosynthesis
	Methionine Metabolism
WikiPathways	Metabolism of amino acids and derivatives
References
Ref 525957	Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol. 2001 Feb;59(2):231-8.
Ref 535793	S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.
Ref 535032	A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. Br J Cancer. 2000 Sep;83(5):594-601.
Ref 535955	New S-adenosylmethionine decarboxylase inhibitors with potent antitumor activity. Cancer Res. 1992 Sep 1;52(17):4712-8.

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