Drug General Information
Drug ID	D0UX0T
Former ID	DIB017041
Drug Name	Milameline
Synonyms	Miramelin; Mirameline; Milameline hydrochloride; PD-129409; RU-35926
Drug Type	Small molecular drug
Indication	Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3]		Discontinued in Phase 3	[540021], [544882]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Formula	C8H14N2O
InChI	InChI=1S/C8H14N2O/c1-10-5-3-4-8(7-10)6-9-11-2/h4,6H,3,5,7H2,1-2H3/b9-6+
InChIKey	YMMXHEYLRHNXAB-RMKNXTFCSA-N
PubChem Compound ID	9571002
PubChem Substance ID	15321665, 23996679, 44709200, 50785486, 57372896, 85210017, 103400578, 104125652, 132616252, 135257223, 137237411, 142880351, 162222713, 179149900, 179323103, 198957021, 226553826
Target and Pathway
Target(s)	Muscarinic receptor	Target Info	Modulator	[525615]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeleton
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540021	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 301).
Ref 544882	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001410)
Ref 525615	Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization. J Pharmacol Exp Ther. 1999 Nov;291(2):812-22.

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