Drug Information

Drug General Information
Drug ID
D0T0GJ
Former ID
DNC001507
Drug Name
VX-497
Drug Type
Small molecular drug
Indication Hepatitis virus infection [ICD9: 573.3; ICD10:K75.9] Discontinued in Phase 2 [546443]
Structure
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2D MOL

3D MOL
Formula
C23H24N4O6
Canonical SMILES
COC1=C(C=CC(=C1)NC(=O)NC2=CC=CC(=C2)CNC(=O)OC3CCOC3)C4=<br />CN=CO4
InChI
1S/C23H24N4O6/c1-30-20-10-17(5-6-19(20)21-12-24-14-32-21)27-22(28)26-16-4-2-3-15(9-16)11-25-23(29)33-18-7-8-31-13-18/h2-6,9-10,12,14,18H,7-8,11,13H2,1H3,(H,25,29)(H2,26,27,28)/t18-/m0/s1
InChIKey
JBPUGFODGPKTDW-SFHVURJKSA-N
CAS Number
CAS 198821-22-6
PubChem Compound ID
153241
PubChem Substance ID
640687, 10251736, 12015083, 14784233, 14857722, 46229554, 47206686, 52470262, 57347884, 103261008, 103998789, 104435748, 128251684, 134223085, 134338650, 134340678, 135110565, 137237685, 137267687, 141966212, 163306660, 175426334, 175426871, 179150134, 184528635, 198954413, 210275043, 210280681, 224157104, 226666702, 242060097, 252479539
Target and Pathway
Target(s) Inosine-5'-monophosphate dehydrogenase Target Info Inhibitor [535145]
References
Ref 546443Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008158)
Ref 535145VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90(5):625-37.

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