Drug Information

Drug General Information
Drug ID
D05SUA
Former ID
DIB010478
Drug Name
A-798
Synonyms
A-429; A-655; A-665798; A-748; A-761; A-780748; A-798; MCHR-1 antagonists (obesity); Melanin concentrating hormone-1 receptor antagonists, Abbott; MCH-1 antagonists (obesity), Abbott; MCHR-1 antagonists (obesity), Abbott
Indication Obesity [ICD9: 278; ICD10:E66] Terminated [548089]
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL
Canonical SMILES
c1(cc(=O)c2cc(ccc2o1)F)C(=O)NC1CCN(CC1)Cc1cc2OCOc2cc1
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Antagonist [532063]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 548089Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021828)
Ref 532063Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function. Endocrinology. 2012 Dec;153(12):6145-54.

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