Drug General Information
Drug ID	D01LPX
Former ID	DIB016317
Drug Name	Linotroban
Synonyms	CL-871502; HN-11500
Drug Type	Small molecular drug
Indication	Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Discontinued in Phase 2	[545440]
Company	Nycomed AS
Structure		Download 2D MOL 3D MOL
Formula	C14H15NO5S2
Canonical SMILES	S(=O)(=O)(OCC(NC(=O)OCc1ccccc1)C(=O)OCC)c1ccc(cc1)C
CAS Number	CAS 120824-80-8
PubChem Compound ID	65940
Target and Pathway
Target(s)	Thromboxane A2 receptor	Target Info	Antagonist	[534495]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Platelet activation
Reactome	Prostanoid ligand receptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
	Thromboxane signalling through TP receptor
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545440	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003261)
Ref 534495	Effects of the novel thromboxane (TXA2) receptor antagonist linotroban on inulin and para-aminohippuric acid clearances in the conscious male and female rat. Arzneimittelforschung. 1997 Sep;47(9):1026-30.

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