Drug Information

Drug General Information
Drug ID
D0RF9T
Former ID
DIB001785
Drug Name
Lexacalcitol
Synonyms
KH-106; KH-1060; MC-1357; Vitamin D3 agonist, Leo
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Discontinued in Phase 2 [539820], [545353]
Company
LEO Pharma A/S
Structure
Download
2D MOL

3D MOL
Formula
C29H48O4
InChI
InChI=1S/C29H48O4/c1-6-29(32,7-2)16-9-17-33-21(4)25-13-14-26-22(10-8-15-28(25,26)5)11-12-23-18-24(30)19-27(31)20(23)3/h11-12,21,24-27,30-32H,3,6-10,13-19H2,1-2,4-5H3/b22-11+,23-12-/t21-,24-,25-,26+,27+,28-/m1/s1
InChIKey
KLZOTDOJMRMLDX-YBBVPDDNSA-N
PubChem Compound ID
5288670
PubChem Substance ID
822635, 7888546, 11041457, 12014546, 14715307, 14784667, 39321024, 50064338, 50264345, 53787932, 57359236, 103347297, 113872531, 126616813, 126665070, 135025894, 135650456, 138439461, 139426841, 184526821, 184812193, 198951177, 223657688, 223860400, 226395233, 251916472, 251917820, 252225015, 252479370
Target and Pathway
Target(s) Vitamin D receptor Target Info Agonist [534521]
KEGG Pathway Endocrine and other factor-regulated calcium reabsorption
Mineral absorption
Tuberculosis
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Vitamin D metabolism and pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Direct p53 effectors
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
Reactome Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Drug Induction of Bile Acid Pathway
Nuclear Receptors
Vitamin D Metabolism
References
Ref 539820(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2775).
Ref 545353Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002985)
Ref 534521The vitamin D analog, KH1060, is rapidly degraded both in vivo and in vitro via several pathways: principal metabolites generated retain significant biological activity. Endocrinology. 1997 Dec;138(12):5485-96.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.