Drug Information
Drug General Information | |||||
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Drug ID |
D0Q5VW
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Former ID |
DNC003581
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Drug Name |
L-778123
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C22H20ClN5O
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Canonical SMILES |
C1CN(C(=O)CN1CC2=CN=CN2CC3=CC=C(C=C3)C#N)C4=CC(=CC=C4)C<br />l
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InChI |
1S/C22H20ClN5O/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18/h1-7,10,12,16H,8-9,13-15H2
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InChIKey |
JNUGFGAVPBYSHF-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Farnesyl protein transferase | Target Info | Modulator | ||
Geranylgeranyltransferase I | Target Info | Modulator | |||
References | |||||
Ref 521452 | ClinicalTrials.gov (NCT00003430) L-778,123 in Treating Patients With Recurrent or Refractory Solid Tumors. U.S. National Institutes of Health. | ||||
Ref 527183 | A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer. Clin Cancer Res. 2004 Aug 15;10(16):5447-54. |
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