Drug General Information
Drug ID	D05WYW
Former ID	DIB013338
Drug Name	L-373890
Indication	Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Terminated	[546669]
Company	Merck & Co Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c(=O)n(c(cc1)C)CC(=O)NCC1CCN(C(=N)N)CC1)NS(=O)(=O)Cc<br />1ccccc1
CAS Number	CAS 187162-33-0
Target and Pathway
Target(s)	Coagulation factor IIa	Target Info	Inhibitor	[534784]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Complement and coagulation cascades
	Regulation of actin cytoskeleton
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Blood coagulation
Pathway Interaction Database	Thrombin/protease-activated receptor (PAR) pathway
	Angiopoietin receptor Tie2-mediated signaling
	FOXA2 and FOXA3 transcription factor networks
	PAR4-mediated thrombin signaling events
	Syndecan-4-mediated signaling events
	PAR1-mediated thrombin signaling events
PathWhiz Pathway	Vitamin K Metabolism
	Coagulation
Reactome	Intrinsic Pathway of Fibrin Clot Formation
	Common Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
	Cell surface interactions at the vascular wall
	Peptide ligand-binding receptors
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	G alpha (q) signalling events
	Thrombin signalling through proteinase activated receptors (PARs)
WikiPathways	Complement and Coagulation Cascades
	Regulation of Actin Cytoskeleton
	IL1 and megakaryotyces in obesity
	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Blood Clotting Cascade
	Gastrin-CREB signalling pathway via PKC and MAPK
	Thrombin signalling through proteinase activated receptors (PARs)
	Platelet Aggregation (Plug Formation)
	GPCR ligand binding
	GPCR downstream signaling
	Formation of Fibrin Clot (Clotting Cascade)
	Cell surface interactions at the vascular wall
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
References
Ref 546669	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009558)
Ref 534784	L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor. Bioorg Med Chem Lett. 1998 Apr 7;8(7):817-22.

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