Drug Information

Drug General Information
Drug ID
D0FY6Q
Former ID
DIB009987
Drug Name
JTK-109
Drug Type
Small molecular drug
Indication HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10:B17.1, B18.2] Discontinued in Phase 1 [547651]
Company
Japan Tobacco Inc
Structure
Download
2D MOL

3D MOL
Formula
C27H26N2O3
Canonical SMILES
C1CC(=O)N(C1)c1ccc(c(c1)COc1cc(c(c2n(C3CCCCC3)c3c(n2)cc<br />(C(=O)O)cc3)cc1)F)c1ccc(cc1)Cl
PubChem Compound ID
491098
Target and Pathway
Target(s) Hepatitis C virus NS5B polymerase Target Info Inhibitor [528324]
References
Ref 547651Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018157)
Ref 528324Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109. J Med Chem. 2006 Jul 27;49(15):4721-36.

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