Drug General Information
Drug ID	D09PTA
Former ID	DIB002342
Drug Name	HP-290
Synonyms	NXX-066
Drug Type	Small molecular drug
Indication	Parkinson's disease [ICD9: 332; ICD10:G20]		Discontinued in Phase 2	[546136]
Company	Astra AB; Hoechst AG
Structure		Download 2D MOL 3D MOL
Formula	C23H27N3O2
Canonical SMILES	[C@]12([C@@H](N(c3c1cc(OC(=O)N1Cc4c(CC1)cccc4)cc3)C)N(C<br />C2)C)C
CAS Number	CAS 139314-01-5
PubChem Compound ID	132228
Target and Pathway
Target(s)	Acetylcholinesterase	Target Info	Inhibitor	[525471]
KEGG Pathway	Glycerophospholipid metabolism
	Cholinergic synapse
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
PathWhiz Pathway	Phospholipid Biosynthesis
WikiPathways	Monoamine Transport
	Biogenic Amine Synthesis
	Acetylcholine Synthesis
	Integrated Pancreatic Cancer Pathway
References
Ref 546136	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006532)
Ref 525471	NXX-066 in patients with Alzheimer's disease: a bridging study. Life Sci. 1999;64(14):1215-21.

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