Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0E1WY
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| Former ID |
DNC009026
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| Drug Name |
EFIPLADIB
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD10:J45] | Terminated | [529485] | ||
| Structure |
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Download2D MOL |
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| Formula |
C40H35Cl3N2O4S
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| Canonical SMILES |
C1=CC=C(C=C1)C(C2=CC=CC=C2)N3C4=C(C=C(C=C4)Cl)C(=C3CCNS<br />(=O)(=O)CC5=CC(=C(C=C5)Cl)Cl)CCCC6=CC=C(C=C6)C(=O)O
|
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| InChI |
1S/C40H35Cl3N2O4S/c41-32-19-21-37-34(25-32)33(13-7-8-27-14-17-31(18-15-27)40(46)47)38(22-23-44-50(48,49)26-28-16-20-35(42)36(43)24-28)45(37)39(29-9-3-1-4-10-29)30-11-5-2-6-12-30/h1-6,9-12,14-21,24-25,39,44H,7-8,13,22-23,26H2,(H,46,47)
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| InChIKey |
HIZOPJQOPKRKFM-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Cytosolic phospholipase A2 | Target Info | Inhibitor | [529940] | |
| BioCyc Pathway | Phospholipases | ||||
| KEGG Pathway | Glycerophospholipid metabolism | ||||
| Ether lipid metabolism | |||||
| Arachidonic acid metabolism | |||||
| Linoleic acid metabolism | |||||
| alpha-Linolenic acid metabolism | |||||
| Metabolic pathways | |||||
| MAPK signaling pathway | |||||
| Ras signaling pathway | |||||
| Vascular smooth muscle contraction | |||||
| VEGF signaling pathway | |||||
| Platelet activation | |||||
| Fc epsilon RI signaling pathway | |||||
| Fc gamma R-mediated phagocytosis | |||||
| Glutamatergic synapse | |||||
| Serotonergic synapse | |||||
| Long-term depression | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| GnRH signaling pathway | |||||
| Ovarian steroidogenesis | |||||
| Oxytocin signaling pathway | |||||
| Choline metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | ||||
| Endothelins | |||||
| PDGFR-beta signaling pathway | |||||
| Signaling mediated by p38-alpha and p38-beta | |||||
| PathWhiz Pathway | Fc Epsilon Receptor I Signaling in Mast Cells | ||||
| References | |||||
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