Drug Information

Drug General Information
Drug ID
D0O6WJ
Former ID
DIB009810
Drug Name
Ecalcidene
Synonyms
Vitamin D3 derivative, Barrier
Drug Type
Small molecular drug
Indication Acne vulgaris [ICD9: 706.1; ICD10:L70.0] Terminated [547789]
Company
Research Institute for Medicine & Chemistry Inc
Structure
Download
2D MOL

3D MOL
Formula
C29H45NO3
Canonical SMILES
C1C/C(=C\C=C/2\C[C@H](C[C@@H](C2=C)O)O)/[C@H]2[C@](C1)(<br />[C@H](CC2)[C@H](CCC(=O)N1CCCCC1)C)C
CAS Number
CAS 150337-94-3
PubChem Compound ID
44152790
Target and Pathway
Target(s) Vitamin D receptor Target Info Modulator [527817]
KEGG Pathway Endocrine and other factor-regulated calcium reabsorption
Mineral absorption
Tuberculosis
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Vitamin D metabolism and pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Direct p53 effectors
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
Reactome Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Drug Induction of Bile Acid Pathway
Nuclear Receptors
Vitamin D Metabolism
References
Ref 547789Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019289)
Ref 527817Degradation chemistry of a Vitamin D analogue (ecalcidene) investigated by HPLC-MS, HPLC-NMR and chemical derivatization. J Pharm Biomed Anal. 2006 Mar 3;40(4):850-63. Epub 2005 Oct 20.

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