Drug General Information
Drug ID	D0T3VO
Former ID	DIB002367
Drug Name	DX-619
Synonyms	Quinolone derivative (injectable, bacterial infection), Daiichi Sankyo
Drug Type	Small molecular drug
Indication	Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99]		Discontinued in Phase 2	[547823]
Company	Daiichi Seiyaku Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C21H24FN3O4
Canonical SMILES	n1(c2c(c(=O)c(c1)C(=O)O)ccc(c2OC)N1C[C@H](C2(CC2)N)CC1)<br />[C@@H]1C[C@@H]1F
PubChem Compound ID	9865774
Target and Pathway
Target(s)	Bacterial DNA gyrase	Target Info	Modulator	[527893]
	Topoisomerase IV	Target Info	Modulator	[527893]
References
Ref 547823	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019670)
Ref 527893	DX-619, a novel des-fluoro(6) quinolone manifesting low frequency of selection of resistant Staphylococcus aureus mutants: quinolone resistance beyond modification of type II topoisomerases. Antimicrob Agents Chemother. 2005 Dec;49(12):5051-7.

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