Drug Information
Drug General Information | |||||
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Drug ID |
D0R2JS
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Former ID |
DIB016627
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Drug Name |
Droloxifene
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Synonyms |
E-droloxifene; FK-435; K-060; K-060E; RP-60850; K-21.060E; 3-hydroxytamoxifen
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Drug Type |
Small molecular drug
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Indication | Breast cancer [ICD9: 174, 175; ICD10:C50] | Discontinued in Phase 2 | [544750] | ||
Company |
Klinge Pharma GmbH
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Structure |
Download2D MOL |
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Formula |
C26H29NO2
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Canonical SMILES |
C(=C(\c1ccccc1)/CC)(/c1cc(O)ccc1)\c1ccc(cc1)OCCN(C)C
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CAS Number |
CAS 82413-20-5
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Estrogen receptor | Target Info | Modulator | [533830] | |
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
Signaling events mediated by HDAC Class II | |||||
Plasma membrane estrogen receptor signaling | |||||
LKB1 signaling events | |||||
Regulation of Telomerase | |||||
ATF-2 transcription factor network | |||||
AP-1 transcription factor network | |||||
FOXM1 transcription factor network | |||||
Validated nuclear estrogen receptor alpha network | |||||
Signaling mediated by p38-alpha and p38-beta | |||||
FOXA1 transcription factor network | |||||
References |
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