Drug Information

Drug General Information
Drug ID
D01HRR
Former ID
DIB006441
Drug Name
Domitroban
Synonyms
Amboxan; Anboxan; S-145; S-1452
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Discontinued in Preregistration [539275], [545002]
Company
Shionogi & Co Ltd
Structure
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2D MOL

3D MOL
Formula
C20H27NO4S
InChI
InChI=1S/C20H27NO4S/c22-19(23)11-7-2-1-6-10-18-15-12-13-16(14-15)20(18)21-26(24,25)17-8-4-3-5-9-17/h1,3-6,8-9,15-16,18,20-21H,2,7,10-14H2,(H,22,23)/b6-1-/t15-,16+,18+,20+/m1/s1
InChIKey
PWTCIBWRMQFJBC-ZEMKZVSASA-N
CAS Number
CAS 132747-47-8
PubChem Compound ID
5312138
PubChem Substance ID
7980461, 11056899, 14804433, 39341757, 50064175, 57359523, 79658938, 114157972, 134222649, 135256692, 135650957, 135651201, 172649176, 180371910, 198948282, 198987781, 226694316, 226694317, 242651861
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Antagonist [533694]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539275(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1979).
Ref 545002Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001843)
Ref 533694The effect of a novel thromboxane A2 (TXA2) receptor antagonist (S-1452) on the antigen-induced bronchoconstriction and airway hyperresponsiveness in guinea pigs. Prostaglandins Leukot Essent Fatty Acids. 1993 May;48(5):343-9.

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