Drug General Information
Drug ID	D06TWE
Former ID	DIB013516
Drug Name	CLX-0921
Synonyms	CLX-090502; CLX-090503; CLX-090717; CLX-092402
Indication	Type 2 diabetes [ICD9: 250; ICD10:E11]		Phase 1	[526686]
Company	Calyx Therapeutics Inc; Calyx Therapeutics
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N1C(=O)SC(C1=O)Cc1ccc(Oc2ccc(/C(=C\c3cc(cc(c3)OC)OC)/C(<br />=O)OC)cc2)cc1
Target and Pathway
Target(s)	Peroxisome proliferator activated receptor gamma	Target Info	Agonist	[526686]
KEGG Pathway	PPAR signaling pathway
	AMPK signaling pathway
	Osteoclast differentiation
	Huntington's disease
	Pathways in cancer
	Transcriptional misregulation in cancer
	Thyroid cancer
NetPath Pathway	IL1 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Leptin Signaling Pathway
PANTHER Pathway	CCKR signaling map ST
Pathway Interaction Database	Noncanonical Wnt signaling pathway
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	Signaling events mediated by HDAC Class I
	RXR and RAR heterodimerization with other nuclear receptor
	Regulation of retinoblastoma protein
Reactome	PPARA activates gene expression
	Transcriptional regulation of white adipocyte differentiation
	Nuclear Receptor transcription pathway
WikiPathways	Wnt Signaling Pathway Netpath
	Nuclear Receptors in Lipid Metabolism and Toxicity
	Differentiation of white and brown adipocyte
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Transcriptional Regulation of White Adipocyte Differentiation
	Adipogenesis
	SREBP signalling
	Nuclear Receptors
References
Ref 526686	A novel peroxisome proliferator-activated gamma (PPAR gamma) agonist, CLX-0921, has potent antihyperglycemic activity with low adipogenic potential. Metabolism. 2003 Aug;52(8):1012-8.
Ref 526686	A novel peroxisome proliferator-activated gamma (PPAR gamma) agonist, CLX-0921, has potent antihyperglycemic activity with low adipogenic potential. Metabolism. 2003 Aug;52(8):1012-8.

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