Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0J2UW
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| Former ID |
DNC000411
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| Drug Name |
CGS 21680
|
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Terminated | [1], [2] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C23H29N7O6
|
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| InChI |
InChI=1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1
|
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| InChIKey |
PAOANWZGLPPROA-RQXXJAGISA-N
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| CAS Number |
CAS 124182-57-6
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7978912, 10748414, 14859889, 24263018, 36416348, 49881014, 50104707, 53790868, 57356012, 78010568, 85856597, 90341157, 103342361, 103980562, 111695205, 128888237, 134341772, 135061368, 135650083, 135651144, 139543640, 140916706, 144233173, 144233174, 152258457, 160647293, 162169286, 162220816, 179590195, 185975553, 198970009, 224517877, 227013111, 249814827, 249814828, 249814829, 252333367
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| Target and Pathway | |||||
| Target(s) | Adenosine A2a receptor | Target Info | Agonist | [3] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| Calcium signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Vascular smooth muscle contraction | |||||
| Parkinson's disease | |||||
| Alcoholism | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| PathWhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | ||||
| Reactome | NGF-independant TRKA activation | ||||
| Adenosine P1 receptors | |||||
| G alpha (s) signalling events | |||||
| Surfactant metabolism | |||||
| WikiPathways | Nucleotide GPCRs | ||||
| Monoamine Transport | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| NGF signalling via TRKA from the plasma membrane | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 375). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000147) | ||||
| REF 3 | Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat. Eur J Pharmacol. 2002 Mar 8;438(3):183-8. | ||||
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