Drug General Information
Drug ID	D0S6VX
Former ID	DIB007375
Drug Name	CGP-40215A
Drug Type	Small molecular drug
Indication	Pneumocystis carinii infection [ICD10:B59]		Terminated	[534214]
Company	Novartis AG
Structure		Download 2D MOL 3D MOL
Formula	C17H22Cl3N9
Canonical SMILES	C(=N)(N/N=C/c1cc(C(=N)N)ccc1)N/N=C/c1cc(C(=N)N)ccc1.Cl.<br />Cl.Cl
CAS Number	CAS 126534-93-8
PubChem Compound ID	9576797
Target and Pathway
Target(s)	S-adenosylmethioninedecarboxylase proenzyme	Target Info	Modulator	[534214], [535793]
BioCyc Pathway	Methionine salvage cycle III
	Spermine biosynthesis
	Spermidine biosynthesis
KEGG Pathway	Cysteine and methionine metabolism
	Arginine and proline metabolism
	Metabolic pathways
NetPath Pathway	EGFR1 Signaling Pathway
PathWhiz Pathway	Spermidine and Spermine Biosynthesis
	Methionine Metabolism
WikiPathways	Metabolism of amino acids and derivatives
References
Ref 534214	Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70.
Ref 534214	Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70.
Ref 535793	S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.

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