Drug Information

Drug General Information
Drug ID
D0KK4U
Former ID
DIB014594
Drug Name
CB-1267
Indication Prostate cancer [ICD9: 185; ICD10:C61] Terminated [546395]
Company
LEO Pharma A/S
Structure
Download
2D MOL

3D MOL
Canonical SMILES
C(C(F)(F)F)(C(F)(F)F)(C#CCOC[C@@H]([C@@H]1[C@@]2([C@H](<br />/C(=C/C=C/3\C(=C)[C@H](C[C@@H](C3)O)O)/CCC2)CC1)C)C)O
CAS Number
CAS 139174-97-3
Target and Pathway
Target(s) Vitamin D receptor Target Info Modulator [525534]
KEGG Pathway Endocrine and other factor-regulated calcium reabsorption
Mineral absorption
Tuberculosis
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Vitamin D metabolism and pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Direct p53 effectors
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
Validated transcriptional targets of deltaNp63 isoforms
Validated transcriptional targets of TAp63 isoforms
Reactome Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Drug Induction of Bile Acid Pathway
Nuclear Receptors
Vitamin D Metabolism
References
Ref 546395Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007891)
Ref 525534Novel 20-epi-vitamin D3 analog combined with 9-cis-retinoic acid markedly inhibits colony growth of prostate cancer cells. Prostate. 1999 Aug 1;40(3):141-9.

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