Drug Information

Drug General Information
Drug ID
D03KWN
Former ID
DIB008856
Drug Name
AZD-6703
Synonyms
P38 MAP kinase inhibitors (rheumatoid arthritis), AstraZeneca
Drug Type
Small molecular drug
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Discontinued in Phase 1 [542667], [548025]
Company
AstraZeneca plc
Structure
Download
2D MOL

3D MOL
Formula
C24H27N5O2
InChI
InChI=1S/C24H27N5O2/c1-16-3-4-17(23(30)26-18-5-6-18)13-22(16)29-15-25-21-8-7-19(14-20(21)24(29)31)28-11-9-27(2)10-12-28/h3-4,7-8,13-15,18H,5-6,9-12H2,1-2H3,(H,26,30)
InChIKey
ZMAZXHICVRYLQN-UHFFFAOYSA-N
PubChem Compound ID
11373432
PubChem Substance ID
16466687, 23528259, 42452660, 79632493, 144231329, 160684005, 160863450, 223366022, 224079117, 227379375, 247953518
Target and Pathway
Target(s) Stress kinase p38 Target Info Inhibitor [531914]
References
Ref 542667(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7687).
Ref 548025Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021256)
Ref 531914The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38alpha MAP kinase inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3879-83.

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