Drug General Information
Drug ID	D08ODH
Former ID	DIB002306
Drug Name	Atiratecan
Synonyms	CH-0793011; CH-0793076; CH-4556300; TP-300
Drug Type	Small molecular drug
Indication	Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21]		Discontinued in Phase 2	[548306]
Company	Chugai Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C31H34N6O6
Canonical SMILES	c1ccc2nc3c(c4c2c1ncn4CCCCC)Cn1c3cc2c(c1=O)COC(=O)[C@@]2<br />(CC)OC(=O)CN(C(=O)CN)C
PubChem Compound ID	11592352
Target and Pathway
Target(s)	Toposisomerase-1	Target Info	Inhibitor	[531647]
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	DNA replication
Pathway Interaction Database	Caspase Cascade in Apoptosis
WikiPathways	Integrated Pancreatic Cancer Pathway
References
Ref 548306	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024385)
Ref 531647	Method development and validation of the simultaneous determination of a novel topoisomerase 1 inhibitor, the prodrug, and the active metabolite in human plasma using column-switching LC-MS/MS, and its application in a clinical trial. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 15;879(30):3415-22.

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