Drug Information

Drug General Information
Drug ID
D0S0OI
Former ID
DNC011520
Drug Name
ATEVIRDINE
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 1 [521415]
Structure
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2D MOL

3D MOL
Formula
C21H25N5O2
Canonical SMILES
CCNC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)OC
InChI
1S/C21H25N5O2/c1-3-22-18-5-4-8-23-20(18)25-9-11-26(12-10-25)21(27)19-14-15-13-16(28-2)6-7-17(15)24-19/h4-8,13-14,22,24H,3,9-12H2,1-2H3
InChIKey
UCPOMLWZWRTIAA-UHFFFAOYSA-N
PubChem Compound ID
60848
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Modulator [534208]
References
Ref 521415ClinicalTrials.gov (NCT00000753) A Phase I Concentration-Targeted Multidose Study of Atevirdine Mesylate ( U-87201E ), AZT, and ddI or ddC. U.S. National Institutes of Health.
Ref 534208J Med Chem. 1996 Sep 13;39(19):3769-89.Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reversetranscriptase inhibitors.

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