Drug General Information |
Drug ID |
D04DDM
|
Former ID |
DNC000812
|
Drug Name |
ISIS 3521
|
Drug Type |
Antisense drug
|
Indication |
Discovery agent
|
Discontinued in Phase 2 |
[1]
|
Therapeutic Class |
Antisense
|
CAS Number |
CAS 107420-91-7
|
SuperDrug ATC ID |
D03AX10
|
SuperDrug CAS ID |
cas=000471534
|
Target and Pathway |
Target(s) |
Protein kinase C, alpha type |
Target Info |
Modulator |
|
KEGG Pathway
|
MAPK signaling pathway
|
ErbB signaling pathway
|
Ras signaling pathway
|
Rap1 signaling pathway
|
Calcium signaling pathway
|
HIF-1 signaling pathway
|
Phosphatidylinositol signaling system
|
Sphingolipid signaling pathway
|
mTOR signaling pathway
|
PI3K-Akt signaling pathway
|
Adrenergic signaling in cardiomyocytes
|
Vascular smooth muscle contraction
|
Wnt signaling pathway
|
VEGF signaling pathway
|
Focal adhesion
|
Tight junction
|
Gap junction
|
Natural killer cell mediated cytotoxicity
|
Fc epsilon RI signaling pathway
|
Fc gamma R-mediated phagocytosis
|
Leukocyte transendothelial migration
|
Circadian entrainment
|
Long-term potentiation
|
Retrograde endocannabinoid signaling
|
Glutamatergic synapse
|
Cholinergic synapse
|
Serotonergic synapse
|
GABAergic synapse
|
Dopaminergic synapse
|
Long-term depression
|
Inflammatory mediator regulation of TRP channels
|
Insulin secretion
|
GnRH signaling pathway
|
Melanogenesis
|
Thyroid hormone synthesis
|
Thyroid hormone signaling pathway
|
Oxytocin signaling pathway
|
Aldosterone-regulated sodium reabsorption
|
Endocrine and other factor-regulated calcium reabsorption
|
Salivary secretion
|
Gastric acid secretion
|
Pancreatic secretion
|
Amphetamine addiction
|
Morphine addiction
|
Vibrio cholerae infection
|
Pathogenic Escherichia coli infection
|
African trypanosomiasis
|
Amoebiasis
|
Hepatitis B
|
Influenza A
|
Pathways in cancer
|
Proteoglycans in cancer
|
MicroRNAs in cancer
|
Glioma
|
Non-small cell lung cancer
|
Choline metabolism in cancer
|
NetPath Pathway
|
IL2 Signaling Pathway
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathway
|
Alzheimer disease-amyloid secretase pathway
|
Angiogenesis
|
Apoptosis signaling pathway
|
EGF receptor signaling pathway
|
Endothelin signaling pathway
|
FGF signaling pathway
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
PDGF signaling pathway
|
VEGF signaling pathway
|
Wnt signaling pathway
|
5HT2 type receptor mediated signaling pathway
|
Histamine H1 receptor mediated signaling pathway
|
Oxytocin receptor mediated signaling pathway
|
Thyrotropin-releasing hormone receptor signaling pathway
|
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
|
CCKR signaling map ST
|
Pathway Interaction Database
|
Endothelins
|
TCR signaling in naï
|
Canonical NF-kappaB pathway
|
Signaling events regulated by Ret tyrosine kinase
|
TCR signaling in naï
|
Thromboxane A2 receptor signaling
|
Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
mTOR signaling pathway
|
Ras signaling in the CD4+ TCR pathway
|
ErbB1 downstream signaling
|
Syndecan-4-mediated signaling events
|
ATF-2 transcription factor network
|
PDGFR-beta signaling pathway
|
Retinoic acid receptors-mediated signaling
|
IL8- and CXCR2-mediated signaling events
|
VEGFR1 specific signals
|
Signaling events mediated by VEGFR1 and VEGFR2
|
PAR1-mediated thrombin signaling events
|
a6b1 and a6b4 Integrin signaling
|
IL8- and CXCR1-mediated signaling events
|
Regulation of Ras family activation
|
Downstream signaling in naï
|
PathWhiz Pathway
|
Fc Epsilon Receptor I Signaling in Mast Cells
|
Activation of PKC through G protein coupled receptor
|
Reactome
|
Calmodulin induced events
|
Disinhibition of SNARE formation
|
Regulation of KIT signaling
|
EGFR Transactivation by Gastrin
|
Inactivation, recovery and regulation of the phototransduction cascade
|
Syndecan interactions
|
Acetylcholine regulates insulin secretion
|
Ca2+ pathway
|
Trafficking of GluR2-containing AMPA receptors
|
G alpha (z) signalling events
|
Depolymerisation of the Nuclear Lamina
|
HuR (ELAVL1) binds and stabilizes mRNA
|
WNT5A-dependent internalization of FZD4
|
VEGFR2 mediated cell proliferation
|
Response to elevated platelet cytosolic Ca2+
|
WikiPathways
|
ErbB Signaling Pathway
|
Calcium Regulation in the Cardiac Cell
|
Insulin Signaling
|
EGF/EGFR Signaling Pathway
|
Wnt Signaling Pathway
|
Wnt Signaling Pathway and Pluripotency
|
Wnt Signaling Pathway Netpath
|
G Protein Signaling Pathways
|
Kit receptor signaling pathway
|
Transcriptional activation by NRF2
|
Myometrial Relaxation and Contraction Pathways
|
Human Complement System
|
Cardiac Hypertrophic Response
|
Syndecan interactions
|
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
Signaling by SCF-KIT
|
DAG and IP3 signaling
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
T-Cell Receptor and Co-stimulatory Signaling
|
Alpha 6 Beta 4 signaling pathway
|
Spinal Cord Injury
|
Integrated Pancreatic Cancer Pathway
|
Oncostatin M Signaling Pathway
|
Corticotropin-releasing hormone
|
AGE/RAGE pathway
|
Pathogenic Escherichia coli infection
|
Signaling Pathways in Glioblastoma
|
Endothelin Pathways
|
Regulation of Microtubule Cytoskeleton
|
FSH signaling pathway
|
miRs in Muscle Cell Differentiation
|
Opioid Signalling
|
Response to elevated platelet cytosolic Ca2+
|
Integration of energy metabolism
|
TOR Signaling
|
References |
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006393) |