Drug Information

Drug General Information
Drug ID
D07DKC
Former ID
DPR000014
Drug Name
Apafant
Synonyms
Apafanto; Apafantum; Triazolodiazepine; WEB 2086BS; WEB2086; Web 2086; Apafant [USAN:INN]; Apafanto [INN-Spanish]; Apafantum [INN-Latin]; DE-081; WEB-2086; 3-(4-(2-chlorophenyl)-9-methyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine-2-yl)-1-(4-morpholinyl)-1-propanone; 4-(3-(4-(o-Chlorophenyl)-9-methyl-6H-thieno(3,2-f)-s-triazolo(4,3-a)(1,4)diazepin-2-yl)propionyl)morpholine; 4-[3-[4-(2-chlorophenyl)-9-methyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxopropyl]morpholine
Drug Type
Small molecular drug
Indication Ocular allergy [ICD9: 360-379; ICD10:H00-H59] Terminated [536119], [539170]
Company
Santen Pharmaceutical
Structure
Download
2D MOL

3D MOL
Formula
C22H22ClN5O2S
InChI
InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
InChIKey
JGPJQFOROWSRRS-UHFFFAOYSA-N
CAS Number
CAS 105219-56-5
PubChem Compound ID
65889
PubChem Substance ID
7848715, 7980891, 8190013, 12013921, 14808862, 26753288, 43122628, 47670896, 47744969, 48268088, 49993653, 50545460, 53787682, 57315807, 58108390, 85209803, 85789087, 91610602, 103186311, 103915258, 104334937, 117465116, 124891592, 124891593, 124894328, 126683013, 128272031, 134339496, 135024015, 135649947, 135651137, 135698199, 144206979, 144207143, 162023346, 163124927, 164835912, 170466052, 179149528, 184536613, 198957763, 204356799, 223468665, 223653758, 226471804, 241375892, 252156455, 252214738, 252339034
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [536119]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 536119Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20.
Ref 539170(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1860).
Ref 536119Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20.

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