Drug Information
Drug General Information | |||||
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Drug ID |
D04DYZ
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Former ID |
DNC003723
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Drug Name |
ABT-839
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Drug Type |
Small molecular drug
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Indication | Non-small cell lung cancer [ICD10:C33-C34] | Terminated | [547261] | ||
Structure |
Download2D MOL |
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Formula |
C32H46N2O3S
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Canonical SMILES |
CCCCN(CCC1CCCCC1)CC2=CC(=C(C=C2)C(=O)NC(CCSC)C(=O)O)C3=<br />CC=CC=C3C
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InChI |
1S/C32H46N2O3S/c1-4-5-19-34(20-17-25-12-7-6-8-13-25)23-26-15-16-28(29(22-26)27-14-10-9-11-24(27)2)31(35)33-30(32(36)37)18-21-38-3/h9-11,14-16,22,25,30H,4-8,12-13,17-21,23H2,1-3H3,(H,33,35)(H,36,37)/t30-/m0/s1
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InChIKey |
GAQHYZNOMLXSEA-PMERELPUSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Farnesyltransferase | Target Info | Inhibitor | [526584] | |
Protein farnesyltransferase beta subunit | Target Info | Inhibitor | [527321] | ||
NetPath Pathway | TSH Signaling Pathway | ||||
References | |||||
Ref 526584 | Bioorg Med Chem Lett. 2003 Apr 7;13(7):1359-62.Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives. | ||||
Ref 527321 | Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8.Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase. |
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