Drug General Information
Drug ID	D02VHE
Former ID	DIB005923
Drug Name	A-72055
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Terminated	[545007]
Company	Abbott Laboratories
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N1(C(OC2(C1)CCN(CC2)C)C)C=O
CAS Number	CAS 150358-76-2
Target and Pathway
Target(s)	Muscarinic receptor	Target Info	Modulator	[550836]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeleton
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545007	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001856)
Ref 550836	US patent application no. 2011,0020,423, Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation.

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