Drug Information

Drug General Information
Drug ID
D0W4JI
Former ID
DIB016111
Drug Name
INS-50589
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Phase 2 [521824], [539120]
Company
Inspire Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C22H25N6O8P
InChI
InChI=1S/C22H25N6O8P/c1-2-23-22(29)27-19-16-20(25-11-24-19)28(12-26-16)21-18-17(14(34-21)10-33-37(30,31)32)35-15(36-18)9-8-13-6-4-3-5-7-13/h3-9,11-12,14-15,17-18,21H,2,10H2,1H3,(H2,30,31,32)(H2,23,24,25,27,29)/b9-8+/t14-,15+,17-,18-,21-/m1/s1
InChIKey
NXHAXEBZOXCDKD-XIXRRVGJSA-N
PubChem Compound ID
11273179
PubChem Substance ID
24843443, 42352659, 46535457, 80928367, 103762261, 135280175, 135650403, 160850681, 175267651
Target and Pathway
Target(s) P2Y purinoceptor 12 Target Info Modulator [528959]
KEGG Pathway Platelet activation
Reactome P2Y receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 521824ClinicalTrials.gov (NCT00316212) Study of INS50589 Intravenous Infusion in Subjects Undergoing Coronary Artery Bypass Grafting (CABG) Involving Cardiopulmonary Bypass. U.S. National Institutes of Health.
Ref 539120(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1770).
Ref 528959Rapid and reversible modulation of platelet function in man by a novel P2Y(12) ADP-receptor antagonist, INS50589. Platelets. 2007 Aug;18(5):346-56.

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