Drug Information

Drug General Information
Drug ID
D0BM5G
Former ID
DAP000462
Drug Name
Tazarotene
Synonyms
Avage; Suretin; Tazaroteno; Tazarotenum; Tazorac; Tazoral; Zorac; AGN 190168; AGN-190168; Avage (TN); Tazarotene [USAN:INN]; Tazorac (TN); Zorac (TN); Tazarotene (JAN/USAN/INN); Tazorac, Avage, Zora, Tazarotene; Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate; Ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate; Ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinate; Ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester; 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-,ethyl ester
Drug Type
Small molecular drug
Indication Psoriasis [ICD9: 696; ICD10:L40] Approved [536361], [541988]
Therapeutic Class
Dermatologic Agents
Company
Allergan Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C21H21NO2S
InChI
InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3
InChIKey
OGQICQVSFDPSEI-UHFFFAOYSA-N
CAS Number
CAS 118292-40-3
PubChem Compound ID
5381
PubChem Substance ID
582921, 4405151, 7848195, 8153307, 12014289, 14754274, 29224433, 46508992, 50031802, 50112778, 53789348, 56352905, 57322745, 68530738, 79123421, 85246194, 92719256, 93166451, 103629338, 104113517, 104253218, 104253308, 104309077, 124757343, 125164147, 125338838, 126620953, 126658167, 126670670, 127300883, 127300884, 127300885, 127300886, 127300887, 127300888, 127300889, 127300890, 127300891, 127300892, 127300893, 127300894, 127300895, 127300896, 127300897, 128806208, 134337757, 135017550, 135692178, 136376512, 136946544
ChEBI ID
ChEBI:32184
SuperDrug ATC ID
D05AX05
SuperDrug CAS ID
cas=118292403
Target and Pathway
Target(s) Retinoic acid receptor gamma Target Info Binder [534998]
Reactome Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Mesodermal Commitment Pathway
Endoderm Differentiation
Nuclear Receptors
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541988(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6952).
Ref 534998Recent developments in receptor-selective retinoids. Curr Pharm Des. 2000 Jun;6(9):919-31.

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