Drug Information

Drug General Information
Drug ID
D0W9MM
Former ID
DAP000785
Drug Name
Vinblastine
Synonyms
Nincaluicolflastine; Rozevin; VLB; Vinblastin; Vinblastina; Vinblastinum; Vincaleucoblastin; Vincaleucoblastine; Vincaleukoblastine; Vincoblastine; Vinblastina [DCIT]; VR-8; Vinblastina (TN); Vinblastine (INN); Vinblastine [INN:BAN]; Vinblastinum [INN-Latin]; NDC 0002-1452-01; (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE; (2xi,3beta,4'beta,19xi)-vincaleukoblastine; 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Approved [541931], [551871]
Therapeutic Class
Anticancer Agents
Company
Eli Lilly And Co
Structure
Download
2D MOL

3D MOL
Formula
C46H58N4O9
InChI
InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
InChIKey
JXLYSJRDGCGARV-CFWMRBGOSA-N
CAS Number
CAS 865-21-4
PubChem Compound ID
13342
PubChem Substance ID
7891062, 8160040, 15945566, 16702846, 24262986, 25641143, 29281493, 46393695, 48034812, 49855966, 50104049, 50637221, 57328088, 85788295, 92718122, 93167219, 103229487, 103924566, 104331509, 124886802, 126628575, 126690312, 127342232, 127342233, 134338070, 134980402, 136126664, 136959342, 137001867, 141857134, 152104919, 162184753, 165280031, 175268513, 178103457, 179335179, 184812178, 223683512, 223832241, 226395766
ChEBI ID
ChEBI:27375
SuperDrug ATC ID
L01CA01
SuperDrug CAS ID
cas=000865214
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Tubulin beta-2 chain Target Info Inhibitor [535740]
References
Ref 541931(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6851).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535740Effect of the antitumor drug vinblastine on nuclear betaII-tubulin in cultured rat kidney mesangial cells. Invest New Drugs. 2003 Feb;21(1):15-20.

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