Drug Information

Drug General Information
Drug ID
D03FNJ
Former ID
DAP000988
Drug Name
Pipobroman
Synonyms
Amedel; Pipobromanum; Vercyte; A 1803; A-8103; Pipobroman [USAN:INN]; Pipobromanum [INN-Latin]; VERCYTE (TN); Pipobroman (JAN/USAN/INN); N,N'-Bis(3-bromopropionyl)piperazine; N,N-Bis-(3-bromopropionyl)-piperazine; 1,4-Bis(3-bromopropanoyl)piperazine; 1,4-Bis(3-bromopropionyl)piperazine; 3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one
Drug Type
Small molecular drug
Indication Refractory chronic myeloid leukaemia [ICD9: 205.1; ICD10:C92.1] Approved [538475], [542291], [551871]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL
Formula
C10H16Br2N2O2
InChI
InChI=1S/C10H16Br2N2O2/c11-3-1-9(15)13-5-7-14(8-6-13)10(16)2-4-12/h1-8H2
InChIKey
NJBFOOCLYDNZJN-UHFFFAOYSA-N
CAS Number
CAS 54-91-1
PubChem Compound ID
4842
PubChem Substance ID
9566, 86412, 220314, 5518519, 7847533, 8149987, 8152976, 10526660, 11335974, 11361213, 11364621, 11367183, 11369745, 11371894, 11377907, 11406401, 11462185, 11484520, 11488728, 11490862, 11495541, 14876527, 26612478, 26680378, 26748793, 26748794, 26748795, 29223923, 46506548, 47216809, 47515347, 47589037, 48416444, 50011390, 50107466, 50733206, 57322482, 92124614, 92307921, 99301887, 103589881, 104307586, 121365257, 124637578, 128709591, 134222726, 134338258, 134971949, 137006686, 137545237
SuperDrug ATC ID
L01AX02
SuperDrug CAS ID
cas=000054911
Target and Pathway
Target(s) DNA Target Info Binder [537776]
References
Ref 538475FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016245.
Ref 542291(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7271).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537776Effects of piposulfan (Ancyte) on protein and DNA synthesis in Ehrlich ascites carcinoma. Life Sci II. 1971 Jun 8;10(11):605-12.

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