Drug Information

Drug General Information
Drug ID
D0B2GI
Former ID
DAP000132
Drug Name
Glimepiride
Synonyms
Amarel; Amaryl; Endial; Glimepirid; Glimepirida; Glimepiridum; Glimepride; Glimer; Glymepirid; Roname; Solosa; Glimepirida [Spanish]; Glimepiridum [Latin]; Sandoz glimepiride; HOE 490; Amaryl (TN); Hoe-490; Novo-glimepiride; PMS-glimepiride; Ratio-glimepiride; Amaryl, Glista OD, Glimepiride; Glimepiride [USAN:BAN:INN]; Glimepiride (JAN/USP/INN); 1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea; 1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea; 3-ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide; 3-ethyl-4-methyl-n-(4-(n-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro; 4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide; 64598P
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Approved [536554], [541902]
Therapeutic Class
Hypoglycemic Agents
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL
Formula
C24H34N4O5S
InChI
InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-
InChIKey
WIGIZIANZCJQQY-RUCARUNLSA-N
CAS Number
CAS 93479-97-1
PubChem Compound ID
3476
PubChem Substance ID
9871, 5043708, 7847659, 7979409, 8145852, 8152210, 11112876, 11466679, 11467799, 11486338, 12013623, 14908413, 24895093, 26719876, 26755029, 26755030, 29222609, 32963623, 46386690, 46508842, 47589079, 47959862, 48155569, 48185080, 48334594, 49648856, 49699123, 49731995, 49835734, 50037704, 50126308, 56313637, 57321825, 77374551, 81040871, 81092812, 85787655, 85787837, 91613422, 92125647, 92308643, 92309214, 92711714, 99344865, 99437102, 103394534, 103543151, 103913636, 104171333, 104303626
ChEBI ID
ChEBI:5383
SuperDrug ATC ID
A10BB12
SuperDrug CAS ID
cas=093479971
Target and Pathway
Target(s) SUR2-type K(ATP) channel Target Info Blocker [537007]
Sulfonylurea receptor 1 Target Info Blocker [537007]
KEGG Pathway ABC transporters
Insulin secretion
Type II diabetes mellitus
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networks
PathWhiz Pathway Muscle/Heart Contraction
Pancreas Function
Reactome ABC-family proteins mediated transport
Regulation of insulin secretion
WikiPathways Potassium Channels
Integration of energy metabolism
References
Ref 536554Clinical utilization of combined rosiglitazone and glimepiride in the treatment of type 2 diabetes mellitus. Orv Hetil. 2007 Dec 9;148(49):2331-5.
Ref 541902(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6820).
Ref 537007Mechanism of disopyramide-induced hypoglycaemia in a patient with Type 2 diabetes. Diabet Med. 2009 Jan;26(1):76-8.

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