Drug Information

Drug General Information
Drug ID
D0CK3G
Former ID
DAP000606
Drug Name
Ethinamate
Synonyms
Ethinamat; Ethinamatum; Ethinimate; Etinamate; Etinamato; Valamid; Valamin; Valaminetta; Valaminettae; Valaminetten; Valmid; Valmidate; Volamin; Ethynylcyclohexyl carbamate; Carbamate de L'ethinylcyclohexanol; Carbamate de l'ethinylcyclohexanol [French]; Ethinamatum [INN-Latin]; Etinamato [INN-Spanish]; USAF EL-42; Valamin (TN); Valmid (TN); Aethinyl-cyclohexyl-carbamat; Aethinyl-cyclohexyl-carbamat [German]; Carbamic acid, 1-ethynylcyclohexyl ester; Ethinamate (JAN/INN); Ethinamate [INN:BAN:JAN]; Cyclohexanol, 1-ethynyl-, carbamate; Cyclohexanol, 1-ethynyl-, 1-carbamate; (1-ethynylcyclohexyl) carbamate; 1-Ethinylcyclohexyl carbamate; 1-Ethinylcyclohexyl carbonate; 1-Ethynylcyclohexanol carbamate; 1-Ethynylcyclohexyl carbamate; 1-ethynylcyclohexylcarbamate
Drug Type
Small molecular drug
Indication Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0] Approved [538422], [542348]
Therapeutic Class
Hypnotics and Sedatives
Structure
Download
2D MOL

3D MOL
Formula
C9H13NO2
InChI
InChI=1S/C9H13NO2/c1-2-9(12-8(10)11)6-4-3-5-7-9/h1H,3-7H2,(H2,10,11)
InChIKey
GXRZIMHKGDIBEW-UHFFFAOYSA-N
CAS Number
CAS 126-52-3
PubChem Compound ID
3284
PubChem Substance ID
10034, 76466, 89573, 90432, 481830, 5235073, 7847768, 8152085, 10506157, 15066627, 24894502, 29222423, 46507468, 48415972, 49958226, 50248345, 57321702, 57654156, 58106949, 99437355, 103589706, 104303062, 126407576, 128021457, 134337897, 134973559, 137005129, 144238877, 160964366, 163224109, 176326023, 178103897, 179225724, 198963123, 221672894, 226428833, 241131632, 249954434
Target and Pathway
Target(s) Carbonic anhydrase II Target Info Inhibitor [535861]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 538422FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009750.
Ref 542348(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7325).
Ref 535861Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50.

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