Drug Information

Drug General Information
Drug ID
D0K3DQ
Former ID
DAP001177
Drug Name
Cefotiam
Synonyms
Aspil; CTM; Cefotiamum; Ceradolan; Haloapor; CEFOTIAM HYDROCHLORIDE; CGP 14221E; Abbott-48999; Aspil (TN); Cefotiam (INN); Cefotiam [INN:BAN]; Cefotiamum [INN-Latin]; SCE-963; CGP-14221-E; (6R,7R)-7-[2-(2-Amino-thiazol-4-yl)-acetylamino]-3-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-ylsulfanylmethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}thio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7b-[2-(aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoethyl)-1h-tetrazol-5-yl]thio]methyl]ceph-3-em-4-carboxylic acid; 7beta-(2-amino-1,3-thiazol-4-yl)acetamido-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-3,4-didehydrocepham-4-carboxylic acid
Drug Type
Small molecular drug
Indication Bacterial respiratory tract infection [ICD10:J13, J15] Approved [536361], [551871]
Therapeutic Class
Antibiotics
Company
Takeda
Structure
Download
2D MOL

3D MOL
Formula
C18H23N9O4S3
Canonical SMILES
CN(C)CCN1C(=NN=N1)SCC2=C(N3C(C(C3=O)NC(=O)CC4=CSC(=N4)N<br />)SC2)C(=O)O
InChI
1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1
InChIKey
QYQDKDWGWDOFFU-IUODEOHRSA-N
CAS Number
CAS 61622-34-2
PubChem Compound ID
43708
PubChem Substance ID
8178318, 11466510, 11467630, 11486000, 14763007, 14836521, 34709097, 46506679, 47662540, 47811024, 47885651, 48334777, 48415723, 49699361, 50050897, 50124314, 50998350, 51091952, 85547195, 85788073, 103401140, 104343035, 117600521, 124766419, 126670035, 134224539, 134338422, 135006449, 136054981, 137006379, 140253709, 143261064, 160963577, 163693587, 164788213, 174549096, 179150782, 196394354, 198976567, 223676320, 226515016, 236431513, 249865493, 251912556, 251916666, 252073508, 252358745
SuperDrug ATC ID
J01DC07
SuperDrug CAS ID
cas=061622342
Target and Pathway
Target(s) Penicillin binding protein 3 Target Info Binder [536184]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536184Genetic analyses of beta-lactamase negative ampicillin-resistant strains of Haemophilus influenzae isolated in Okinawa, Japan. Jpn J Infect Dis. 2006 Feb;59(1):36-41.

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