Drug Information

Drug General Information
Drug ID
D07ZTO
Former ID
DAP000263
Drug Name
Bethanechol
Synonyms
Amidopropyldimethylbetaine; Bethanecol; Urabeth; Myotonine chloride; Duvoid (TN); Myotonachol (TN); Urecholine (TN); Carbamoyl-beta-methylcholine; Carbamyl-beta-methylcholine; Ammonium, (2-hydroxypropyl)trimethyl-, carbamate (ester); (2-Hydroxypropyl)trimethylammonium carbamate; 1-Propanaminium, 2-((aminocarbonyl)oxy)-N,N,N-trimethyl-(9CI); 2-((Aminocarbonyl)oxy)-N,N,N-trimethyl-1-propanaminium; 2-(carbamoyloxy)-N,N,N-trimethylpropan-1-aminium; 2-carbamoyloxypropyl(trimethyl)azanium; 2-carbamoyloxypropyl-trimethylazanium
Drug Type
Small molecular drug
Indication Urinary retention [ICD9: 788.2; ICD10:R33] Approved [538184], [539981]
Therapeutic Class
Parasympathomimetics
Company
Merck & Co
Structure
Download
2D MOL

3D MOL
Formula
C7H17N2O2+
InChI
InChI=1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1
InChIKey
NZUPCNDJBJXXRF-UHFFFAOYSA-O
CAS Number
CAS 674-38-4
PubChem Compound ID
2370
PubChem Substance ID
9068, 4422030, 4918193, 8151589, 11335354, 11360593, 11362918, 11365480, 11368042, 11371502, 11373829, 11376204, 11461565, 11467101, 11468221, 11483940, 11486729, 11487948, 11490127, 11492070, 11493898, 26756574, 29221538, 46507707, 47810623, 47810624, 48034978, 48110329, 48184868, 48259086, 48259087, 48259088, 49698975, 49868462, 50105244, 57321286, 77420552, 90341349, 92308844, 92729933, 103544258, 104300395, 124749610, 124879658, 124879659, 124879661, 124879662, 128778196, 131269063, 134337577
SuperDrug ATC ID
N07AB02
SuperDrug CAS ID
cas=000674384
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M5 Target Info Agonist [536978], [536985], [537156]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538184FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040518.
Ref 539981(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 297).
Ref 536978Postoperative analgesia induced by intrathecal neostigmine or bethanechol in rats. Clin Exp Pharmacol Physiol. 2009 Jul;36(7):648-54. Epub 2008 Nov 28.
Ref 536985Morphine increases acetylcholine release in the trigeminal nuclear complex. Sleep. 2008 Dec 1;31(12):1629-37.
Ref 537156Loss of Ca-mediated ion transport during colitis correlates with reduced ion transport responses to a Ca-activated K channel opener. Br J Pharmacol. 2009 Apr;156(7):1085-97. Epub 2009 Mar 9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.