Drug Information

Drug General Information
Drug ID
D0M2MC
Former ID
DAP000860
Drug Name
Phenmetrazine
Synonyms
Cafilon; Defenmetrazin; Dexphenmetrazine; Fenmetrazin; Fenmetrazina; Oxazimedrine; Phenmetraline; Phenmetrazin; Phenmetrazinum; Preludin hydrochloride; A 66; Psychamine A 66; Bontril (TN); Defenmetrazin (TN); Fenmetrazin (TN); Fenmetrazina [INN-Spanish]; Oxazimedrine (TN); Phenmetraline (TN); Phenmetrazine [INN:BAN]; Phenmetrazinum [INN-Latin]; Dl-2-Phenyl-3-methyltetrahydro-1,4-oxazine; 2-Fenyl-3-methylmorfolin; 2-Fenyl-3-methylmorfolin [Czech]; 2-Phenyl-3-methylmorpholine; 3-Methyl-2-phenylmorpholine; 3-Methyl-2-phenyltetrahydro-2H-1,4-oxazine
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Approved [550743]
Therapeutic Class
Appetite Depressants
Company
Boehringer Ingelheim GmbH
Structure
Download
2D MOL

3D MOL
Formula
C11H15NO
Canonical SMILES
CC1C(OCCN1)C2=CC=CC=C2
InChI
1S/C11H15NO/c1-9-11(13-8-7-12-9)10-5-3-2-4-6-10/h2-6,9,11-12H,7-8H2,1H3
InChIKey
OOBHFESNSZDWIU-UHFFFAOYSA-N
CAS Number
CAS 134-49-6
PubChem Compound ID
4762
PubChem Substance ID
9636, 4437709, 7980290, 8152923, 10506941, 15322006, 26757954, 29223846, 46504524, 48416414, 49994179, 50420966, 57322435, 92714657, 95613288, 104307352, 108210008, 124582671, 124893147, 126629462, 128836902, 134223759, 134338139, 134975074, 137089239, 141905910, 143440995, 160964172, 162208475, 163258024, 164174564, 170507515, 174534923, 176265247, 179226016, 184605388, 198935988, 212295757, 223364442, 226420514, 242111128, 249524148, 249933220
Target and Pathway
Target(s) Dopamine reuptake Target Info Inhibitor [535503]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [535503]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 550743Drug information of Phenmetrazine, 2008. eduDrugs.
Ref 535503Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain. Eur J Pharmacol. 2002 Jun 28;447(1):51-7.

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