Drug Information

Drug General Information
Drug ID
D04FBR
Former ID
DAP000783
Drug Name
Mycophenolate mofetil
Synonyms
CellCept; MMF; Munoloc; Mycophenolic acid morpholinoethyl ester; Mycophenylate mofetil; RS 61443; CellCept (TN); Cellcept (TN); ME-MPA; MMF CellCept(TM); R-99; RS-61443; TM-MMF; Mycophenolate mofetil (JAN/USAN); RS-61443-190; CellCept, RS 61443, TM-MMF, Mycophenolate mofetil; 2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate; 2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate; 2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate; 2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate;4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
Drug Type
Small molecular drug
Indication Organ transplant rejection [ICD9: 279.5, 996; ICD10:D89.8, T86] Approved [536737], [541912]
Pemphigus vulgaris [ICD9: 694.4; ICD10:L10.0] Phase 3 [536737], [541912]
Therapeutic Class
Immunosuppressive Agents
Company
Roche
Structure
Download
2D MOL

3D MOL
Formula
C23H31NO7
InChI
InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+
InChIKey
RTGDFNSFWBGLEC-SYZQJQIISA-N
CAS Number
CAS 128794-94-5
PubChem Compound ID
5281078
PubChem Substance ID
10110, 537396, 623972, 7847817, 8616507, 12014254, 14758955, 29215410, 39289999, 46505626, 48416299, 49830660, 49976609, 50064190, 56310881, 56312885, 57358003, 62129612, 77319688, 80954261, 92308999, 92718908, 93619754, 96099842, 103524891, 103831140, 104253178, 113854519, 117622077, 118053002, 124757298, 125164102, 125275456, 126592936, 126621236, 126622394, 126651543, 126669998, 126682700, 131295332, 131297141, 132003527, 134338068, 134339833, 135016986, 135039794, 136949095, 137004579, 142385187, 144075766
SuperDrug ATC ID
L04AA06
Target and Pathway
Target(s) Inosine-5'-monophosphate dehydrogenase 2 Target Info Inhibitor [551607]
BioCyc Pathway Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Guanosine nucleotides de novo biosynthesis
Superpathway of purine nucleotide salvage
Purine nucleotides de novo biosynthesis
Guanosine ribonucleotides de novo biosynthesis
KEGG Pathway Purine metabolism
Drug metabolism - other enzymes
Metabolic pathways
PANTHER Pathway De novo purine biosynthesis
Reactome Purine ribonucleoside monophosphate biosynthesis
References
Ref 536737Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
Ref 541912(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6831).
Ref 551607Clinical pipeline report, company report or official report of Roche (2009).

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