Drug Information

Drug General Information
Drug ID
D0G5AG
Former ID
DAP001404
Drug Name
Mizoribine
Synonyms
Bredinin; Bredinine; MZR; Mizoribina; Mizoribinum; M 3047; Bredinin (TN); HE-69; HS-0046; Mizoribina [INN-Spanish]; Mizoribine [INN:JAN]; Mizoribinum [INN-Latin]; Mizoribine (JAN/INN); Bredinin, HE 69, NSC 289637, MZB, Mizoribine; Anhydro-4-carbamoyl-5-hydroxy-1-beta-D-ribofuranosyl-imidazolium hydroxide; N'-(beta-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide; N'-(beta-D-Ribofuranosyl)-5-hydroxy-imida-zole-4-carboxamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide;4-Carbamoyl-1-beta-D-ribofuranosyl-imidazolium-5-olate; 4-carbamoyl-1-b-d-ribofuranosylimidazolium-5-olate; 5-Hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide; 5-Hydroxy-1-beta-D-ribofuranosylimidazole-4-carboxamide
Drug Type
Small molecular drug
Indication Hyperuricemia; Transplant rejection [ICD9: 790.6, 279.5, 996; ICD10:E79.0, D89.8, T86] Approved [536361], [551871]
Therapeutic Class
Antimetabolites
Structure
Download
2D MOL

3D MOL
Formula
C9H13N3O6
Canonical SMILES
C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N
InChI
1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1
InChIKey
HZQDCMWJEBCWBR-UUOKFMHZSA-N
CAS Number
CAS 50924-49-7
PubChem Compound ID
104762
PubChem Substance ID
815565, 7848455, 8150076, 10233595, 11336123, 11361362, 11371618, 11373998, 11462334, 11485174, 11489375, 11490555, 11492035, 11532986, 12013753, 14750114, 14798922, 14872303, 15196996, 17405306, 24278546, 26679836, 37235031, 44434374, 47515385, 47515386, 47736571, 47959845, 48259320, 49979230, 50106568, 50106569, 50106570, 50303271, 53777851, 56424022, 57337827, 90340602, 91010689, 92304153, 92721415, 92729691, 93815047, 99302036, 99431405, 99437125, 103138275, 103525173, 104372869, 117565393
Target and Pathway
Target(s) Inosine-5'-monophosphate dehydrogenase Target Info Inhibitor [535145], [535945]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535145VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90(5):625-37.
Ref 535945Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target. Curr Med Chem. 2004 Apr;11(7):887-900.

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