Drug Information
Drug General Information | |||||
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Drug ID |
D0X1EZ
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Former ID |
DIB000385
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Drug Name |
Cyclofenil
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Drug Type |
Small molecular drug
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Indication | Infertility [ICD9: 628; ICD10:N97.0] | Approved | [551871] | ||
Structure |
Download2D MOL |
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Formula |
C23H24O4
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Canonical SMILES |
CC(=O)Oc1ccc(cc1)C(=C2CCCCC2)c3ccc(OC(=O)C)cc3
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InChI |
1S/C23H24O4/c1-16(24)26-21-12-8-19(9-13-21)23(18-6-4-3-5-7-18)20-10-14-22(15-11-20)27-17(2)25/h8-15H,3-7H2,1-2H3
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InChIKey |
GVOUFPWUYJWQSK-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Estrogen receptor | Target Info | Modulator | [528133], [551871] | |
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
Signaling events mediated by HDAC Class II | |||||
Plasma membrane estrogen receptor signaling | |||||
LKB1 signaling events | |||||
Regulation of Telomerase | |||||
ATF-2 transcription factor network | |||||
AP-1 transcription factor network | |||||
FOXM1 transcription factor network | |||||
Validated nuclear estrogen receptor alpha network | |||||
Signaling mediated by p38-alpha and p38-beta | |||||
FOXA1 transcription factor network | |||||
References | |||||
Ref 528133 | Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential positron emission tomography agents for imaging estrogen receptors in breast cancer. J Med Chem. 2006 Apr 20;49(8):2496-511. | ||||
Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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