Drug Information

Drug General Information
Drug ID
D0CP4E
Former ID
DAP000259
Drug Name
Clonazepam
Synonyms
Antelepsin; Antilepsin; Chlonazepam; Cloazepam; Clonazepamum; Clonex; Clonopin; Iktorivil; Kenoket; Klonopin; Landsen; Lktorivil; Lonazep; Melzap; Paxam; Ravotril; Rivatril; Rivoril; Rivotril; Solfidin; Klonopin Rapidly Disintegrating; DF2374250; RO4023; Ro 4023; Ro 54023; Alti-Clonazepam; Clonazepamum [INN-Latin]; Klonopin (TN); Ravotril (TN); Rivatril (TN); Rivotril (TN); Ro 4-8180; Ro 5-4023; Ro-5-4023; Clonazepam (JP15/USP/INN); Clonazepam [USAN:INN:BAN:JAN]; Ro 5-4023/B-7; 1,3-Dihydro-5-(o-chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2-one; 1,3-Dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one; 5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one; 5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one; 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 5-(2-Chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2(1H)-one; 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one; 5-(o-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one; 5-(o-Chlorophenyl)-7-nitro-1H-1,4-benzodiazepin-2(3H)-one; 5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Nitro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one
Drug Type
Small molecular drug
Indication Epilepsy [ICD10:G40] Approved [538277], [541998]
Seizures [ICD9: 345.9, 780.3; ICD10:G40, P90, R56] Phase 2 [529439], [534170], [541998]
Therapeutic Class
Anticonvulsants
Company
Roche Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C15H10ClN3O3
InChI
InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)
InChIKey
DGBIGWXXNGSACT-UHFFFAOYSA-N
CAS Number
CAS 1622-61-3
PubChem Compound ID
2802
PubChem Substance ID
447045, 629452, 4807399, 6242864, 7847346, 7978973, 8150128, 8151811, 10503355, 10509779, 10589180, 11109648, 11336148, 11361387, 11462359, 12146087, 14874486, 24892396, 29221957, 46507677, 47702094, 47736576, 48415805, 49884102, 49884205, 50876639, 56313737, 57321471, 85176029, 92307992, 92714482, 92729733, 93167162, 96026525, 96079552, 99302061, 103165964, 103930203, 104301655, 125536639, 126624103, 126655374, 126691438, 127729747, 131300953, 134337573, 134979678, 135315111, 136949632, 137002943
SuperDrug ATC ID
N03AE01
SuperDrug CAS ID
cas=001622613
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor Target Info Agonist [535248], [536166]
References
Ref 529439Residual effect of a 7-amino metabolite of clonazepam on GABAA receptor function in the nucleus reticularis thalami of the rat. Epilepsia. 2008 Oct;49(10):1803-8.
Ref 534170Characterization of GABAA receptor function in human temporal cortical neurons. J Neurophysiol. 1996 Apr;75(4):1458-71.
Ref 538277FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074569.
Ref 541998(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6963).
Ref 535248Hyperekplexia in neonates. Postgrad Med J. 2001 Sep;77(911):570-2.
Ref 536166Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.

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