Drug Information

Drug General Information
Drug ID
D0J9HW
Former ID
DCL000583
Drug Name
Olaparib
Synonyms
AZD 2281; AZD2281; AZD-2281; Acylpiperazine analogue, 47; KU-0059436; KU-59436; Olaparib, KU-0059436, AZD2281,KU0059436, AZD2281; 4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one; 4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
Drug Type
Small molecular drug
Indication Breast cancer; Ovarian cancer [ICD9: 174, 175, 183; ICD10:C50, C56] Approved [542530], [550296]
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL
Formula
C24H23FN4O3
InChI
InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
InChIKey
FDLYAMZZIXQODN-UHFFFAOYSA-N
CAS Number
CAS 763113-22-0
PubChem Compound ID
23725625
PubChem Substance ID
47209066, 56053773, 57299275, 85197660, 93581006, 99436961, 103605183, 109692964, 117670453, 118049496, 121277945, 123051082, 124490470, 124756970, 124947876, 125163775, 125312522, 125415525, 126582065, 126626885, 126644879, 126664211, 126666996, 126738835, 131407195, 131465127, 134213960, 134222742, 134338825, 134339140, 134346179, 134964396, 135261055, 135697767, 135708109, 135723596, 135727477, 136368068, 136377786, 136895641, 136920280, 137005640, 137255348, 141853509, 143499369, 144115666, 152237700, 152258100, 152344243, 160646939
Target and Pathway
Target(s) Poly ADP ribose polymerase (PARP) Target Info Modulator [533123]
References
Ref 542530(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7519).
Ref 550296LYNPARZA? approved by the US food and drug administration for the treatment of advanced ovarian cancer in patients with germline BRCA-mutations
Ref 5331232014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.

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