Drug General Information
Drug ID
D0J9HW
Former ID
DCL000583
Drug Name
Olaparib
Synonyms
AZD 2281; AZD2281; AZD-2281; Acylpiperazine analogue, 47; KU-0059436; KU-59436; Olaparib, KU-0059436, AZD2281,KU0059436, AZD2281; 4-[(3-{[4-Cyclopropylcarbonyl)piperazin-4-yl]carbonyl}-4-fluorophenyl)methyl]phtalazin-1(2H)-one; 4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one
Drug Type
Small molecular drug
Indication Breast cancer; Ovarian cancer [ICD9: 174, 175, 183; ICD10:C50, C56] Approved [542530], [550296]
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL

Formula
C24H23FN4O3
InChI
InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
InChIKey
FDLYAMZZIXQODN-UHFFFAOYSA-N
CAS Number
CAS 763113-22-0
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Poly ADP ribose polymerase (PARP) Target Info Modulator [533123]
References
Ref 542530(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7519).
Ref 550296LYNPARZA? approved by the US food and drug administration for the treatment of advanced ovarian cancer in patients with germline BRCA-mutations
Ref 5331232014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.

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