Drug General Information
Drug ID
D02CTS
Former ID
DCL001219
Drug Name
Ospemifene
Drug Type
Small molecular drug
Indication Dyspareunia [ICD10:N94.1] Approved [532651], [542369]
Post-menopausal vaginal atrophy [ICD9: 627.3; ICD10:N95.2] Phase 3 [542369], [551684]
Company
Shionogi; QuatRx
Structure
Download
2D MOL

3D MOL

Formula
C24H23ClO2
InChI
InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-
InChIKey
LUMKNAVTFCDUIE-VHXPQNKSSA-N
CAS Number
CAS 128607-22-7
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
G03XC05
Target and Pathway
Target(s) Estrogen receptor Target Info Modulator [551684]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancer
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
JAK/STAT
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear Receptors
References
Ref 5326512013 FDA drug approvals. Nat Rev Drug Discov. 2014 Feb;13(2):85-9.
Ref 542369(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7349).
Ref 551684Clinical pipeline report, company report or official report of Shionogi (2011).
Ref 551684Clinical pipeline report, company report or official report of Shionogi (2011).

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