Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09VXM
|
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| Former ID |
DNAP001270
|
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| Drug Name |
Crofelemer
|
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| Synonyms |
Fulyzaq (TN)
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| Drug Type |
Small molecular drug
|
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| Company |
Salix
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C18H16N2O3
|
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| Canonical SMILES |
COC1=CC=CC=C1CNC(=O)C2=NOC(=C2)C3=CC=CC=C3
|
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| InChI |
1S/C18H16N2O3/c1-22-16-10-6-5-9-14(16)12-19-18(21)15-11-17(23-20-15)13-7-3-2-4-8-13/h2-11H,12H2,1H3,(H,19,21)
|
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| InChIKey |
JDNAIBCYTQGWFC-UHFFFAOYSA-N
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| CAS Number |
CAS 148465-45-6
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | calcium activated channel anoctamin 1 | Target Info | Modulator | [530433], [532210] | |
| cystic fibrosis transmembrane conductance regulator | Target Info | Modulator | [530433], [532210] | ||
| WikiPathways | ABC-family proteins mediated transport | ||||
| References | |||||
| Ref 530433 | Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels. Mol Pharmacol. 2010 Jan;77(1):69-78. | ||||
| Ref 532210 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | ||||
| Ref 542477 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7453). | ||||
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