Drug Information

Drug General Information
Drug ID
D05FGG
Former ID
DCL000490
Drug Name
Azilsartan
Synonyms
TAK 536; TAK-536; Azilsartan (INN/USAN)
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [541957], [551719]
Company
Takeda
Structure
Download
2D MOL

3D MOL
Formula
C25H20N4O5
InChI
InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32)
InChIKey
KGSXMPPBFPAXLY-UHFFFAOYSA-N
CAS Number
CAS 147403-03-0
PubChem Compound ID
9825285
PubChem Substance ID
14784428, 14833581, 24127892, 44923423, 76847538, 85210070, 96025547, 103244284, 103951947, 128380015, 128380016, 134213509, 134348772, 134358743, 135203003, 136946516, 137229628, 139483677, 140904462, 144115313, 160645922, 162009745, 162172206, 162255215, 163686146, 164045364, 164216180, 164836101, 171578929, 172918178, 175265877, 175437730, 176247781, 178103483, 185979069, 189562169, 198993038, 210280800, 211534879, 223383337, 223573547, 223573548, 223659741, 223963167, 226529482, 241036926, 241377053, 249582132, 249617126, 251916420
Target and Pathway
Target(s) Type-1 angiotensin II receptor Target Info Modulator [531783]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Renin-angiotensin system
Renin secretion
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway Angiotensin Metabolism
Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Allograft Rejection
GPCR ligand binding
GPCR downstream signaling
References
Ref 541957(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6901).
Ref 551719Clinical pipeline report, company report or official report of Takeda.
Ref 5317832011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.

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